Article
Genome-wide homozygosity signatures and childhood acute lymphoblastic leukemia risk.
Blood - 3 Jun 2010
Hosking Fay J, Papaemmanuil Elli, Sheridan Eammon, Kinsey Sally E, Lightfoot Tracy, Roman Eve, Irving Julie A E, Allan James M, Taylor Malcolm, Tomlinson Ian P, Greaves Mel, Houlston Richard S
Abstract excerpt
Recent studies have reported that regions of homozygosity (ROH) in the genome are detectable in outbred populations and can be associated with an increased risk of malignancy. To examine whether homozygosity is associated with an increased risk of developing childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL), we analyzed 824 ALL cases and 2398 controls genotyped for 292 200 tagging SNPs. Across the...
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