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Article

Detecting autozygosity through runs of homozygosity: a comparison of three autozygosity detection algorithms.

BMC genomics - 23 Sept 2011

Howrigan Daniel P, Simonson Matthew A, Keller Matthew C

Abstract excerpt

BACKGROUND: A central aim for studying runs of homozygosity (ROHs) in genome-wide SNP data is to detect the effects of autozygosity (stretches of the two homologous chromosomes within the same individual that are identical by descent) on phenotypes. However, it is unknown which current ROH detection program, and which set of parameters within a given program, is optimal for differentiating ROHs that are truly...

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PMID: 21943305
DOI: 10.1186/1471-2164-12-460
PMCID: PMC3188534

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