Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Engineering of human induced pluripotent stem cells via human artificial chromosome vectors for cell therapy and disease modeling

18 Dec 2020

Abstract excerpt

Genetic engineering of induced pluripotent stem cells (iPSCs) holds great promise for gene and cell therapy as well as drug discovery. However, there are potential concerns regarding the safety and control of gene expression using conventional vectors such as viruses and plasmids. Although human artificial chromosome (HAC) vectors have several advantages as a gene delivery vector, including stable episomal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomedical Ethics and Regulation
Share to CRISPR and Genetic Engineering
Share to Pluripotent Stem Cells Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33552683
DOI: 10.1016/j.omtn.2020.12.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Engineering of human induced pluripotent stem cells via human artificial chromosome vectors for cell therapy and disease modelingPMID 33552683Read ↗

Episomal Induced Pluripotent Stem Cells: Functional and Potential Therapeutic ApplicationsSemantic proximity Read ↗

Human Cell Line Panel With Human/Mouse Artificial Chromosomes for Functional Analyses of Desired GenesSemantic proximity Read ↗

New approaches for the generation of induced pluripotent stem cellsSemantic proximity Read ↗

Engineering of Human Pluripotent Stem Cells by AAV-mediated Gene TargetingSemantic proximity Read ↗

Complete Genetic Correction of iPS Cells From Duchenne Muscular DystrophySemantic proximity Read ↗

Concise Review: Human Cell Engineering: Cellular Reprogramming and Genome EditingSemantic proximity Read ↗

Find and replace: editing human genome in pluripotent stem cells.Semantic proximity Read ↗

Directed evolution of adeno-associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells.Semantic proximity Read ↗

Secreted Particle Information Transfer (SPIT) – A Cellular Platform for <i>In Vivo</i> Genetic EngineeringSemantic proximity Read ↗

Adenoviral Gene Delivery Can Reprogram Human Fibroblasts to Induced Pluripotent Stem CellsSemantic proximity Read ↗

Baculoviral transduction facilitates TALEN-mediated targeted transgene integration and Cre/LoxP cassette exchange in human-induced pluripotent stem cells.Semantic proximity Read ↗

Stem cell therapies and benefaction of somatic cell nuclear transfer cloning in COVID-19 eraSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.