Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias.

Proceedings of the National Academy of Sciences of the United States of America - 19 Aug 2003

Jaiswal Siddhartha, Traver David, Miyamoto Toshihiro, Akashi Koichi, Lagasse Eric, Weissman Irving L

Abstract excerpt

Chronic myelogenous leukemia is a myeloproliferative disorder (MPD) that, over time, progresses to acute leukemia. Both processes are closely associated with the t(9;22) chromosomal translocation that creates the BCR/ABL fusion gene in hematopoietic stem cells (HSCs) and their progeny. Chronic my...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Crosses, Genetic
Share to Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, abl

Share to Genes, bcl-2

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Mice, Transgenic

Share to Myeloid Progenitor Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 12890867
DOI: 10.1073/pnas.1633833100
PMCID: PMC187741

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12890867-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias.PMID 12890867Read ↗

Regulated expression of P210 Bcr-Abl during embryonic stem cell differentiation stimulates multipotential progenitor expansion and myeloid cell fateSemantic proximity Read ↗

Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia.Semantic proximity Read ↗

Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis.Semantic proximity Read ↗

Myeloproliferative disease in transgenic mice expressing P230 Bcr/Abl: longer disease latency, thrombocytosis, and mild leukocytosis.Semantic proximity Read ↗

Efficient transplantation of BCR-ABL-induced chronic myelogenous leukemia-like syndrome in mice.Semantic proximity Read ↗

Molecular biology of chronic myeloid leukemia.Semantic proximity Read ↗

Expression of BCR/ABL p210 from a knockin allele enhances bone marrow engraftment without inducing neoplasia.Semantic proximity Read ↗

Blast crisis in a murine model of chronic myelogenous leukemia.Semantic proximity Read ↗

Acquired loss of p53 induces blastic transformation in p210bcr/abl-expressing hematopoietic cells: a transgenic study for blast crisis of human CMLSemantic proximity Read ↗

Graft-versus-Leukemia (GVL) against Mouse Blast-Crisis Chronic Myelogenous Leukemia (BC-CML) and Chronic-Phase Chronic Myelogenous Leukemia (CP-CML): Shared Mechanisms of T Cell Killing, but Programmed Death Ligands Render CP-CML and Not BC-CML GVL ResistantSemantic proximity Read ↗

BCR-ABL gene rearrangement and expression of primitive hematopoietic progenitors in chronic myeloid leukemiaSemantic proximity Read ↗

Model mice for BCR/ABL-positive leukemias.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.