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Cellular Cofactors of Lentiviral Integrase: From Target Validation to Drug Discovery

7 Aug 2012

Abstract excerpt

To accomplish their life cycle, lentiviruses make use of host proteins, the so-called cellular cofactors. Interactions between host cell and viral proteins during early stages of lentiviral infection provide attractive new antiviral targets. The insertion of lentiviral cDNA in a host cell chromosome is a step of no return in the replication cycle, after which the host cell becomes a permanent carrier of the viral...

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PMID: 22928108
DOI: 10.1155/2012/863405

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