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Article

A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75.

PLoS pathogens - 1 Jan 2009

Hare Stephen, Shun Ming-Chieh, Gupta Saumya Shree, Valkov Eugene, Engelman Alan, Cherepanov Peter

Abstract excerpt

Lens epithelium derived growth factor (LEDGF), also known as PC4 and SFRS1 interacting protein 1 (PSIP1) and transcriptional co-activator p75, is the cellular binding partner of lentiviral integrase (IN) proteins. LEDGF accounts for the characteristic propensity of Lentivirus to integrate within active transcription units and is required for efficient viral replication. We now present a crystal structure...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Human Immunodeficiency Virus Proteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 19132083
DOI: 10.1371/journal.ppat.1000259
PMCID: PMC2606027

Genes

PSIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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