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Article

Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75

31 Oct 2005

Abstract excerpt

Integrase (IN) is an essential retroviral enzyme, and human transcriptional coactivator p75, which is also referred to as lens epithelium-derived growth factor (LEDGF), is the dominant cellular binding partner of HIV-1 IN. Here, we report the crystal structure of the dimeric catalytic core domain of HIV-1 IN complexed to the IN-binding domain of LEDGF. Previously identified LEDGF hotspot residues anchor the...

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PMID: 16260736
DOI: 10.1073/pnas.0506924102

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Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75PMID 16260736Read ↗

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