Article
Genetic characterization of adenovirus transformed cell revertants resistant to methylglyoxal bis(guanylhydrazone): evidence for the involvement of three genetic loci.
Journal of cellular physiology - 1 May 1991
Alami N, Chopra A, Thirion J P
Abstract excerpt
Five new independent rat somatic cell mutants resistant to the antileukemic drug methylglyoxal bis(guanylhydrazone) (MGBG) were isolated after mutagen treatment. The mutants were 7- to 10-fold more resistant to MGBG than were the parental wild-type cells. When the MGBG-resistant (MGR) mutants wer...
Topics
- Adenoviridae
- Animals
- Blotting, Southern
- Cell Line
- Cell Line, Transformed
- Cell Transformation, Viral
- Drug Resistance
- Genetic Complementation Test
- Mitoguazone
- Neoplasm Transplantation
- Phenotype
- Polysorbates
- Rats