Article
Dominant expression of multidrug resistance in intraspecific murine lymphoma hybrid cells.
Cancer chemotherapy and pharmacology - 1 Jan 1994
Pályi I, Turi G, Hullán L, Szikla K, Bak M
Abstract excerpt
Cultured P388/VCR mouse lymphoma cells resistant to vincristine (VCR) and to 5-bromodeoxyuridine (BUdR) and deficient in thymidine kinase (TK-) were fused with P388/DAG cells resistant to 1.2:5,6-dianhydrogalactitol (DAG), an anticancer alkylating agent, and to 6-thioguanine (6-TG) and deficient in hypoxanthine phosphoribosyl-transferase (HPRT-). The hybrid cells expressed multidrug resistance (MDR), i.e.,...
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