Effect of antioxidants on the mitochondrial activity and toxicity of the cancer drug methylglyoxal bis (guanylhydrazone) in yeast and mammalian cells.

doi:10.1016/0304-3835(90)90105-7

Back to search

Article

Effect of antioxidants on the mitochondrial activity and toxicity of the cancer drug methylglyoxal bis (guanylhydrazone) in yeast and mammalian cells.

Cancer letters - 15 Jun 1990

Cheng L L, Collier D C, Wilkie D

Abstract excerpt

Mitochondria of yeast cells were primary targets of methylglyoxal bis (guanylhydrazone) (MGBG) from the following criteria: (1) selective inhibition of growth of cells utilizing a non-fermentable energy source, (2) inhibition of mitochondrial protein synthesis compared with cytosolic protein synt...

Topics

Animals
Antioxidants
Cell Division
Cell Survival
Cells, Cultured
Drug Interactions
Glucose
Glutamine
Glycerol
Guinea Pigs
Keratinocytes
Mitochondria
Mitoguazone
Mutation
Saccharomyces cerevisiae
Spectrophotometry

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.