Article
Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966.
PLoS genetics - 1 Mar 2009
Sovio Ulla, Bennett Amanda J, Millwood Iona Y, Molitor John, O'Reilly Paul F, Timpson Nicholas J, Kaakinen Marika, Laitinen Jaana, Haukka Jari, Pillas Demetris, Tzoulaki Ioanna, Molitor Jassy, Hoggart Clive, Coin Lachlan J M, Whittaker John, Pouta Anneli, Hartikainen Anna-Liisa, Freimer Nelson B, Widen Elisabeth, Peltonen Leena, Elliott Paul, McCarthy Mark I, Jarvelin Marjo-Riitta
Abstract excerpt
Recent genome-wide association (GWA) studies have identified dozens of common variants associated with adult height. However, it is unknown how these variants influence height growth during childhood. We derived peak height velocity in infancy (PHV1) and puberty (PHV2) and timing of pubertal height growth spurt from parametric growth curves fitted to longitudinal height growth data to test their association with...
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