Article
Genetics in neuroendocrine immunology: implications for rheumatoid arthritis and osteoarthritis.
Annals of the New York Academy of Sciences - 1 Apr 2010
Stark Klaus, Straub Rainer H, Blazicková Stanislava, Hengstenberg Christian, Rovenský Jozef
Abstract excerpt
Both genetic and environmental factors contribute to rheumatoid arthritis (RA) as well as osteoarthritis (OA). For RA, most of the known genetic markers are linked with genes from immunological pathways. Recent genome-wide association studies (GWAS) on RA identified known and novel susceptibility genes like HLA-DRB1, PTPN22, STAT4, TRAF1/C5, OLIG3/TNFAIP3, CD40, CCL21, MMEL1-TNFRSF14, CDK6, PRKCQ, IL2RB, and...
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