Article
Association of serotonin transporter promoter gene polymorphism (5-HTTLPR) with depression in Costa Rican schizophrenic patients.
Journal of neurogenetics - 1 Jul 2010
Contreras Javier, Hernández Sandra, Quezada Paulina, Dassori Albana, Walss-Bass Consuelo, Escamilla Michael, Raventos Henriette
Abstract excerpt
Depression and suicidal behavior are frequently observed in patients with schizophrenia. The serotonin transporter protein regulates serotonergic signaling at synapses and is encoded by a single gene (SLC6A4; Locus Link ID: 6532), located at 17q11.1-q12 with two polymorphic variants (the short and the long allele). The short allele of serotonin transporter gene has been associated with depression and suicidality...
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