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Article

Regulation of the VHL/HIF-1 Pathway by DJ-1

4 Jun 2014

Abstract excerpt

DJ-1 (PARK7) is a gene linked to autosomal recessive Parkinson disease (PD). We showed previously that DJ-1 loss sensitizes neurons in models of PD and stroke. However, the biochemical mechanisms underlying this protective role are not completely clear. Here, we identify Von Hippel Lindau (VHL) protein as a critical DJ-1-interacting protein. We provide evidence that DJ-1 negatively regulates VHL ubiquitination...

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Identifiers

PMID: 24899725
DOI: 10.1523/jneurosci.1244-13.2014

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