Genetic variation that predicts platinum sensitivity reveals the role of miR-193b* in chemotherapeutic susceptibility.

doi:10.1158/1535-7163.MCT-12-0221

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Article

Genetic variation that predicts platinum sensitivity reveals the role of miR-193b* in chemotherapeutic susceptibility.

Molecular cancer therapeutics - 1 Sept 2012

Ziliak Dana, Gamazon Eric R, Lacroix Bonnie, Kyung Im Hae, Wen Yujia, Huang Rong Stephanie

Abstract excerpt

Platinum agents are the backbone of cancer chemotherapy. Recently, we identified and replicated the role of a single nucleotide polymorphism (SNP, rs1649942) in predicting platinum sensitivity both in vitro and in vivo. Using the CEU samples from the International HapMap Project, we found the same SNP to be a master regulator of multiple gene expression phenotypes, prompting us to investigate whether...

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Identifiers

PMID: 22752226
DOI: 10.1158/1535-7163.MCT-12-0221
PMCID: PMC3438340

Genes

CRIM1
KCNMA1
OAS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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