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Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development

14 Apr 2010

Abstract excerpt

Mice deficient in c-fms-like tyrosine kinase 3 (FLT3) signaling have reductions in early multipotent and lymphoid progenitors, whereas no evident myeloid phenotype has been reported. However, activating mutations of Flt3 are among the most common genetic events in acute myeloid leukemia and mice harboring internal tandem duplications within Flt3 (Flt3-ITD) develop myeloproliferative disease, with characteristic...

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PMID: 20393130
DOI: 10.1182/blood-2009-12-258756

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