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Article

Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool.

Immunity - 1 Oct 2002

Sitnicka Ewa, Bryder David, Theilgaard-Mönch Kim, Buza-Vidas Natalija, Adolfsson Jörgen, Jacobsen Sten Eirik W

Abstract excerpt

The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regulator of this process, in that adult mice deficient in expression of the flt3 ligand (FL) have...

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PMID: 12387740
DOI: 10.1016/s1074-7613(02)00419-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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