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Article

Mutations of PTEN gene in gliomas correlate to tumor differentiation and short-term survival rate.

Anticancer research - 1 Mar 2010

Yang Yiling, Shao Naiyuan, Luo Guanghua, Li Lu, Zheng Lu, Nilsson-Ehle Peter, Xu Ning

Abstract excerpt

The present study determined mutations of phosphatase and tensin homolog (PTEN) gene in patients suffering from high-grade gliomas (WHO grades III and IV) and further investigated the mutations in correlation to patients' histopathological classification and short-term survival. Total RNA and genomic DNA were extracted from tumor tissues. Full-length PTEN cDNA sequences were amplified by polymerase chain reaction...

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Source

Identifiers

PMID: 20393024

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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