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Article

Hypogonadotropic hypogonadism and GNRH1 mutations in mice and humans.

Frontiers of hormone research - 1 Jan 2010

Bouligand Jérôme, Ghervan Cristina, Guiochon-Mantel Anne, Young Jacques

Abstract excerpt

The neuropeptide gonadotropin-releasing hormone (GnRH) plays a key regulatory role in mammalian reproduction. It is synthesized by hypothalamic neurons and released from nerve endings into the portal circulation. After binding to membrane GnRH type 1 receptors on gonadotropic cells of the anterior pituitary, it stimulates the synthesis and release of luteinizing hormone and follicle-stimulating hormone. These two...

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Identifiers

PMID: 20389089
DOI: 10.1159/000312697

Genes

GNRH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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