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Article

Genetics defects in GNRH1: a paradigm of hypothalamic congenital gonadotropin deficiency.

Brain research - 10 Dec 2010

Bouligand Jérôme, Ghervan Cristina, Trabado Séverine, Brailly-Tabard Sylvie, Guiochon-Mantel Anne, Young Jacques

Abstract excerpt

Gonadotropin-releasing hormone (GnRH) is a crucial neurohormone regulating puberty and reproduction in non primate mammals, monkeys and humans. This neuropeptide is released in synchronized pulses from the nerve endings of several hundred GnRH neurons into the hypophyseal portal system to stimulate the biosynthesis and secretion of LH and FSH from pituitary gonadotrophs. These two dimeric glycoprotein hormones in...

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Source

Identifiers

PMID: 20887715
DOI: 10.1016/j.brainres.2010.09.084

Genes

GNRH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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