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Article

GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism.

Proceedings of the National Academy of Sciences of the United States of America - 14 Jul 2009

Chan Yee-Ming, de Guillebon Adelaide, Lang-Muritano Mariarosaria, Plummer Lacey, Cerrato Felecia, Tsiaras Sarah, Gaspert Ariana, Lavoie Hélène B, Wu Ching-Hui, Crowley William F, Amory John K, Pitteloud Nelly, Seminara Stephanie B

Abstract excerpt

Idiopathic hypogonadotropic hypogonadism (IHH) is a condition characterized by failure to undergo puberty in the setting of low sex steroids and low gonadotropins. IHH is due to abnormal secretion or action of the master reproductive hormone gonadotropin-releasing hormone (GnRH). Several genes have been found to be mutated in patients with IHH, yet to date no mutations have been identified in the most obvious...

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Source

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Identifiers

PMID: 19567835
DOI: 10.1073/pnas.0903449106
PMCID: PMC2710623

Genes

GNRH1
IHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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