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Article

Transcriptional Networks and Cellular Senescence in Human Mammary Fibroblasts

2 Dec 2004

Abstract excerpt

Senescence, the molecular program that limits the finite proliferative potential of a cell, acts as an important barrier to protect the body from cancer. Techniques for measuring transcriptome changes and for modulating their expression suggest that it may be possible to dissect the transcriptional networks underlying complex cellular processes. HMF3A cells are conditionally immortalized human mammary fibroblasts...

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PMID: 15574883
DOI: 10.1091/mbc.e04-05-0392

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