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Article

Characterization of hepatitis B virus reverse transcriptase sequences in Chinese treatment naive patients.

Journal of gastroenterology and hepatology - 1 Aug 2009

Han Yue, Huang Li Hua, Liu Chuan Miao, Yang Shu, Li Juan, Lin Zhi Mei, Kong Xiao Fei, Yu De Min, Zhang Dong Hua, Jin Gen Di, Lu Zhi Meng, Gong Qi Ming, Zhang Xin Xin

Abstract excerpt

BACKGROUND AND AIMS: The hepatitis B virus (HBV) reverse transcriptase (RT) plays an important role in viral replication. The aim of the present study was to characterize profiles of the RT region and to construct a database for further studies. METHODS: Serum samples were obtained from 328 treatment naive patients chronically infected with HBV in five Chinese cities. Mutation status, genotypes and deep sequence...

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PMID: 19486254
DOI: 10.1111/j.1440-1746.2009.05864.x

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