Article
[Comparative analysis of drug resistant mutations in the reverse transcriptase domain of hepatitis B virus covalently closed circular DNA and the viral relax circle DNA].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology - 1 Nov 2010
Su He-ling, Liu Yong-ming, Ren Xiao-qiang, Xu Dong-ping, Zhong Yan-wei
Abstract excerpt
OBJECTIVE: To establish a method for detection of reverse transcriptase region of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA), and to compare the pattern and frequency of drug-resistant mutations in the region between intrahepatic HBV cccDNA and serum HBV relax circle DNA (rcDNA). METHODS: HBV DNA were extracted from liver biopsy tissues of 20 patients with chronic hepatitis B. The RT region...
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