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Article

HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells.

Nature communications - 25 Aug 2017

Wang Wen-Fang, Yan Li, Liu Zhao, Liu Lan-Xuan, Lin Jian, Liu Zhi-Yin, Chen Xiong-Ping, Zhang Wu, Xu Zi-Zhen, Shi Ting, Li Jun-Min, Zhao Yi-Lei, Meng Guoyu, Xia Yi, Li Jian-Yong, Zhu Jiang

Abstract excerpt

B lymphocyte-induced maturation protein-1 (Blimp-1) ensures B-cell differentiation into the plasma cell stage, and its instability constitutes a crucial oncogenic element in certain aggressive cases of activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL). However, the underlying degradation mechanisms and their possible therapeutic relevance remain unexplored. Here, we show that N-terminal misfolding...

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Share to HSP70 Heat-Shock Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma, Large B-Cell, Diffuse

Share to Mice, Inbred NOD

Share to Mice, SCID

Share to Positive Regulatory Domain I-Binding Factor 1

Share to Protein Folding

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Source

Open in PubMed Open full text

Identifiers

PMID: 28842558
DOI: 10.1038/s41467-017-00476-w
PMCID: PMC5572455

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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