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Article

Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts.

PloS one - 8 Mar 2011

Rakovic Aleksandar, Grünewald Anne, Kottwitz Jan, Brüggemann Norbert, Pramstaller Peter P, Lohmann Katja, Klein Christine

Abstract excerpt

PINK1 and Parkin mutations cause recessive Parkinson's disease (PD). In Drosophila and SH-SY5Y cells, Parkin is recruited by PINK1 to damaged mitochondria, where it ubiquitinates Mitofusins and consequently promotes mitochondrial fission and mitophagy.Here, we investigated the impact of mutations in endogenous PINK1 and Parkin on the ubiquitination of mitochondrial fusion and fission factors and the mitochondrial...

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Source

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Identifiers

PMID: 21408142
DOI: 10.1371/journal.pone.0016746
PMCID: PMC3050809

Genes

PINK1
OPA1

Provenance

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Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts.PMID 21408142Read ↗

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin.Semantic proximity Read ↗

How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?Semantic proximity Read ↗

PINK1-parkin-dependent mitophagy involves ubiquitination of mitofusins 1 and 2: Implications for Parkinson disease pathogenesisSemantic proximity Read ↗

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagySemantic proximity Read ↗

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1.Semantic proximity Read ↗

The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway.Semantic proximity Read ↗

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila.Semantic proximity Read ↗

Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling.Semantic proximity Read ↗

Reciprocal Regulation of Mitofusin 2-Mediated Mitophagy and Mitochondrial Fusion by Different PINK1 Phosphorylation EventsSemantic proximity Read ↗

Global ubiquitylation analysis of mitochondria in primary neurons identifies physiological Parkin targets following activation of PINK1Semantic proximity Read ↗

Mitofusins: Disease Gatekeepers and Hubs in Mitochondrial Quality Control by E3 LigasesSemantic proximity Read ↗

Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neuronsSemantic proximity Read ↗

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