Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNA-Seq transcriptome profiling identifies CRISPLD2 as a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells.

PloS one - 1 Jan 2014

Himes Blanca E, Jiang Xiaofeng, Wagner Peter, Hu Ruoxi, Wang Qiyu, Klanderman Barbara, Whitaker Reid M, Duan Qingling, Lasky-Su Jessica, Nikolos Christina, Jester William, Johnson Martin, Panettieri Reynold A, Tantisira Kelan G, Weiss Scott T, Lu Quan

Abstract excerpt

Asthma is a chronic inflammatory respiratory disease that affects over 300 million people worldwide. Glucocorticoids are a mainstay therapy for asthma because they exert anti-inflammatory effects in multiple lung tissues, including the airway smooth muscle (ASM). However, the mechanism by which g...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Administration, Inhalation
Share to Anti-Inflammatory Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Asthma

Share to Cell Adhesion Molecules

Share to Dexamethasone

Share to Interferon Regulatory Factors

Share to Muscle, Smooth

Share to Sequence Analysis, RNA

Source

Open in PubMed Open full text

Identifiers

PMID: 24926665
DOI: 10.1371/journal.pone.0099625
PMCID: PMC4057123

Genes

CRISPLD2
CCDC69
DUSP1
KLF15
PER1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24926665-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNA-Seq transcriptome profiling identifies CRISPLD2 as a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells.PMID 24926665Read ↗

Glucocorticoid Receptor ChIP-Seq Identifies PLCD1 as a KLF15 Target that Represses Airway Smooth Muscle HypertrophySemantic proximity Read ↗

SMARCA2 is an essential and potent cofactor for a specific subset of the glucocorticoid response in A549 cellsSemantic proximity Read ↗

From gene identifications to therapeutic targets for asthma: Focus on great potentials of TSLP, ORMDL3, and GSDMBSemantic proximity Read ↗

Glucocorticoid-induced Changes in Gene Expression of Airway Smooth Muscle in Patients with AsthmaSemantic proximity Read ↗

Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cellsSemantic proximity Read ↗

GSDMB/ORMDL3 Rare/Common Variants Are Associated with Inhaled Corticosteroid Response among Children with Asthma.Semantic proximity Read ↗

Multiomics analysis identifies BIRC3 as a novel glucocorticoid response-associated gene.Semantic proximity Read ↗

Integrative analysis of macrophage ribo-Seq and RNA-Seq data define glucocorticoid receptor regulated inflammatory response genes into distinct regulatory classesSemantic proximity Read ↗

Single-cell transcriptomic analysis reveals the immune landscape of lung in steroid-resistant asthma exacerbationSemantic proximity Read ↗

A unique dexamethasone-dependent gene expression profile in the lungs of COVID-19 patientsSemantic proximity Read ↗

Glucocorticoid signaling in pancreatic islets modulates gene regulatory programs and genetic risk of type 2 diabetes.Semantic proximity Read ↗

Glucocorticoids regulate the human non-coding genomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.