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Detection of mutant p53 using field-effect transistor biosensor.

Analytica chimica acta - 14 Apr 2010

Han Sang Hee, Kim Sang Kyu, Park Kyoungsook, Yi So Yeon, Park Hye-Jung, Lyu Hong-Kun, Kim Moonil, Chung Bong Hyun

Abstract excerpt

We assessed the abilities of wild p53 and mutant p53 proteins to interact with the consensus DNA-binding sequence using a MOSFET biosensor. This is the first report in which mutant p53 has been detected on the basis of DNA-protein interaction using a FET-type biosensor. In an effort to evaluate the performance of this protocol, we constructed the core domain of wild p53 and mutant p53 (R248W), which is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20381694
DOI: 10.1016/j.aca.2010.03.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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