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Article

A high-fat diet induced depression-like phenotype via hypocretin-HCRTR1 mediated inflammation activation.

Food & function - 27 Aug 2024

Dong Jingyi, Zhang Jinghui, Cheng Shangping, Qin Bin, Jin Kangyu, Chen Bing, Zhang Yuyan, Lu Jing

Abstract excerpt

Background: A high-fat diet (HFD) is generally associated with an increased risk of mental disorders that constitute a sizeable worldwide health. A HFD results in the gut microbiota-brain axis being altered and linked to mental disorders. Hypocretin-1, which can promote appetite, has been previously confirmed to be associated with depression. However, no exact relationship has been found for hypocretin between...

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PMID: 39056112
DOI: 10.1039/d4fo00210e

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