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Bacillus safensis NMCC-189 attenuates chronic restraint stress-induced depressive phenotypes and modulates neurochemical and gene expression changes in mice.

Biochemical and biophysical research communications - 9 Jul 2026

Sherwani Maryam Khan, Khan Jehan Zeb, Zainab Syeda Rida, Mazhar Muhammad Usama, Ghazanfar Shakira, Tipu Muhammad Khalid

Abstract excerpt

The microbiota-gut-brain axis has been associated with depression, and probiotics are considered potential modulators of stress-related neurobiological processes. This study compared the effects of Bacillus safensis NMCC-189, administered alone or in combination with fluoxetine, in a murine model of chronic restraint stress. The animals were euthanised at predetermined intervals (days 7, 14, and 21; n = 5 per...

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PMID: 42107402
DOI: 10.1016/j.bbrc.2026.153882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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