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Article

Variation at the ADAM10 gene locus is not associated with Creutzfeldt-Jakob disease.

Neuroscience letters - 26 Jun 2003

Plamont Marie-Aude, Chasseigneaux Stéphanie, Delasnerie-Lauprêtre Nicole, Beaudry Patrice, Peoc'h Katell, Laplanche Jean-Louis

Abstract excerpt

Prion diseases are characterized by the accumulation in the brain of a misfolded and protease-resistant form of the prion protein (PrP(c)). PrP(c) contains an amyloidogenic, neurotoxic sequence that is essential for conversion into PrP(Sc), the pathological isoform. During normal processing, PrP(c) is cleaved at a site within this sequence, and this cleavage is thought to destroy the amyloidogenic potential of...

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Source

Identifiers

PMID: 12782344
DOI: 10.1016/s0304-3940(03)00364-1

Genes

ADAM10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variation at the ADAM10 gene locus is not associated with Creutzfeldt-Jakob disease.PMID 12782344Read ↗

Evidence against a role for rare ADAM10 mutations in sporadic Alzheimer disease.Semantic proximity Read ↗

ADAM10 Gene Variants in AD Patients and Their Relationship to CSF Protein LevelsSemantic proximity Read ↗

Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivoSemantic proximity Read ↗

Lack of evidence to support the association of polymorphisms within the alpha- and beta-secretase genes (ADAM10/BACE1) with Alzheimer's disease.Semantic proximity Read ↗

RARB and STMN2 polymorphisms are not associated with sporadic Creutzfeldt-Jakob disease (CJD) in the Korean population.Semantic proximity Read ↗

PRNP 1368 polymorphism is not associated with sporadic Creutzfeldt-Jakob disease in the Korean population.Semantic proximity Read ↗

Polymorphisms in the prion protein gene and in the doppel gene increase susceptibility for Creutzfeldt-Jakob disease.Semantic proximity Read ↗

Genetic epidemiology of Creutzfeldt-Jakob disease in Europe.Semantic proximity Read ↗

Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity.Semantic proximity Read ↗

Lack of association between PRNP 1368 polymorphism and Alzheimer's disease or vascular dementia.Semantic proximity Read ↗

Codon 129 polymorphism of prion protein gene in sporadic Alzheimer's disease.Semantic proximity Read ↗

Lack of association between 14-3-3 beta gene (YWHAB) polymorphisms and sporadic Creutzfeldt-Jakob disease (CJD).Semantic proximity Read ↗

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