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Article

Copy number variation, gene expression and histological localization of human beta-defensin 2 in patients with adeno-tonsillar hypertrophy.

Biotechnic & histochemistry : official publication of the Biological Stain Commission - 1 Nov 2020

Celsi Fulvio, Zupin Luisa, Athanasakis Emmanouil, Orzan Eva, Grasso Domenico Leonardo, Crovella Sergio

Abstract excerpt

Both bacterial infections and innate oral immunity response participate in development of adeno-tonsillar hypertrophy (ATH). ATH can lead to obstructive sleep apnea. We investigated the beta-defensin 2 (hBD-2) encoding gene, DEFB4, by analyzing the copy number variations (CNVs) of the defensin gene cluster in patients with ATH and by correlating CNV with DEFB4 gene expression. We enrolled 79 patients with ATH, 21...

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PMID: 32551953
DOI: 10.1080/10520295.2020.1752936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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