Article
Promoter polymorphism -119C/G in MYG1 (C12orf10) gene is related to vitiligo susceptibility and Arg4Gln affects mitochondrial entrance of Myg1.
BMC medical genetics - 8 Apr 2010
Philips Mari-Anne, Kingo Külli, Karelson Maire, Rätsep Ranno, Aunin Eerik, Reimann Ene, Reemann Paula, Porosaar Orm, Vikeså Jonas, Nielsen Finn C, Vasar Eero, Silm Helgi, Kõks Sulev
Abstract excerpt
BACKGROUND: MYG1 (Melanocyte proliferating gene 1, also C12orf10 in human) is a ubiquitous nucleo-mitochondrial protein, involved in early developmental processes and in adult stress/illness conditions. We recently showed that MYG1 mRNA expression is elevated in the skin of vitiligo patients. Our aim was to examine nine known polymorphisms in the MYG1 gene, to investigate their functionality, and to study their...
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