Article
The catalase gene promoter and 5'-untranslated region variants lead to altered gene expression and enzyme activity in vitiligo.
The British journal of dermatology - 1 Dec 2017
Mansuri M S, Jadeja S D, Singh M, Laddha N C, Dwivedi M, Begum R
Abstract excerpt
BACKGROUND: Oxidative stress is considered to be the initial event in the course of vitiligo. The enzyme catalase (CAT) is mainly involved in cellular defence against oxidizing agents through detoxifying H2 O2 . OBJECTIVES: The aims were (i) to assess erythrocyte CAT enzyme activity and lipid peroxidation (LPO) levels as well as CAT mRNA expression in skin and blood; (ii) to investigate CAT gene promoter...
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