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Article

A functional single-nucleotide polymorphism in the catechol-O-methyltransferase gene alter vitiligo risk in a Chinese population.

Archives of dermatological research - 1 Oct 2009

Li Kai, Li Chunying, Gao Lin, Yang Li, Li Miao, Liu Ling, Zhang Zhengdong, Liu Yufeng, Gao Tianwen

Abstract excerpt

Vitiligo is an acquired hypomelanotic skin disorder resulting from the loss of functional melanocytes. The COMT-158 polymorphism can reduce COMT enzyme activity and may thus lead to the overproduction of toxic radicals in the melanocyte microenvironment. To determine whether this polymorphism in...

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Source

Identifiers

PMID: 19112571
DOI: 10.1007/s00403-008-0920-8

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19112571-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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A functional single-nucleotide polymorphism in the catechol-O-methyltransferase gene alter vitiligo risk in a Chinese population.PMID 19112571Read ↗

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