Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders.

Molecular vision - 3 Apr 2010

Fingert John H, Alward Wallace L, Wang Kai, Yorio Thomas, Clark Abbot F

Abstract excerpt

PURPOSE: While chronic glucocorticoid (GC) therapy leads to ocular hypertension in about one third of individuals, almost all primary open-angle glaucoma (POAG) patients show this response and are called "steroid responders." Two differentially spliced isoforms of the glucocorticoid receptor (GR), GRalpha and GRbeta, regulate GC responsiveness in trabecular meshwork (TM) cells. GRbeta acts as a dominant negative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to FKBP5 gene
Share to Gene Frequency
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glaucoma, Open-Angle

Share to Glucocorticoids

Share to Polymorphism, Single Nucleotide

Share to Receptors, Glucocorticoid

Source

Open in PubMed Open full text

Identifiers

PMID: 20376328
PMCID: PMC2848919

Genes

FKBP4
FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders.PMID 20376328Read ↗

Regulation of Glucocorticoid Responsiveness in Glaucomatous Trabecular Meshwork Cells by Glucocorticoid Receptor-βSemantic proximity Read ↗

Pharmacogenomics of steroid-induced ocular hypertension: relationship to high-tension glaucomas and new pathophysiologic insightSemantic proximity Read ↗

Glucocorticoid receptor gene variant in the 3' untranslated region is associated with multiple measures of blood pressure.Semantic proximity Read ↗

Time-dependent Glucocorticoid-Induced Transcriptomic Changes in Human Trabecular Meshwork and Schlemm’s CanalSemantic proximity Read ↗

Identification of natural human glucocorticoid receptor (hGR) mutations or polymorphisms and their functional consequences at the hormone-receptor interaction level.Semantic proximity Read ↗

[Study on single nucleotide polymorphism of TIGR gene in primary open-angle glaucoma patients].Semantic proximity Read ↗

Uncovering a multitude of human glucocorticoid receptor variants: an expansive survey of a single geneSemantic proximity Read ↗

Human glucocorticoid receptor alpha gene (NR3C1) pharmacogenomics: gene resequencing and functional genomics.Semantic proximity Read ↗

A novel method for monitoring glucocorticoid-induced changes of the glucocorticoid receptor in kidney transplant recipients.Semantic proximity Read ↗

Molecular evidence for a link between the N363S glucocorticoid receptor polymorphism and altered gene expression.Semantic proximity Read ↗

[Study on the gene mutation of TIGR in primary open angle glaucoma, their relatives and normal controls in Chongqing].Semantic proximity Read ↗

The mineralocorticoid receptor modulates timing and location of genomic binding by glucocorticoid receptor in response to synthetic glucocorticoids in keratinocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.