Regulation of Glucocorticoid Responsiveness in Glaucomatous Trabecular Meshwork Cells by Glucocorticoid Receptor-β

Abstract excerpt

PURPOSE: Glucocorticoid administration can lead to increased intraocular pressure in greater than 90% of patients with primary open-angle glaucoma (POAG), compared with 30% to 40% of the general population. The molecular mechanisms for increased steroid responsiveness among patients with glaucoma are unknown. An alternative splicing variant of the human glucocorticoid receptor GRbeta has dominant negative...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Glaucoma and retinal disorders
• Share to Retinal Development and Disorders
• Share to Retinal Diseases and Treatments