Article
Leukemic mutations in the methylation-associated genes DNMT3A and IDH2 are rare events in pediatric AML: a report from the Children's Oncology Group.
Pediatric blood & cancer - 1 Aug 2011
Ho Phoenix A, Kutny Matthew A, Alonzo Todd A, Gerbing Robert B, Joaquin Jason, Raimondi Susana C, Gamis Alan S, Meshinchi Soheil
Abstract excerpt
BACKGROUND: Mutations in the DNMT3A, TET2, IDH1, and IDH2 genes carry prognostic significance and occur frequently in adult acute myeloid leukemia (AML). Leukemic mutations in all four genes have recently been implicated in aberrant DNA methylation, a hallmark of neoplasia. We previously reported that IDH1 mutations were absent, whereas TET2 mutations were present in 6%, of pediatric AML patients; in the present...
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