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Article

Loss of in vitro resistance in Candida glabrata following discontinuation of fluconazole prophylaxis in a hematopoietic stem cell transplantation patient.

Medical mycology - 1 May 2010

Westbrook Steven D, Wiederhold Nathan P, Vallor Ana C, Kotara Susann, Bernardo Stella, Lee Samuel A, Kirkpatrick William R, Toro Juan J, Freytes Cesaro, Patterson Thomas F, Redding Spencer W

Abstract excerpt

We report a case of fluconazole-resistant oropharyngeal colonization caused by a strain of Candida glabrata that rapidly regained susceptibility once prophylaxis with this agent was discontinued and echinocandin therapy was initiated. Isolates collected before and after discontinuation of fluconazole were confirmed to be isogenic by RAPD analysis. Transcription analysis demonstrated constitutive expression of...

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Identifiers

PMID: 20370365
DOI: 10.3109/13693780903213504
PMCID: PMC2856480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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