Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Optimization of Polymyxin B in Combination with Doripenem To Combat Mutator Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 1 May 2016

Ly Neang S, Bulman Zackery P, Bulitta Jürgen B, Baron Christopher, Rao Gauri G, Holden Patricia N, Li Jian, Sutton Mark D, Tsuji Brian T

Abstract excerpt

Development of spontaneous mutations in Pseudomonas aeruginosa has been associated with antibiotic failure, leading to high rates of morbidity and mortality. Our objective was to evaluate the pharmacodynamics of polymyxin B combinations against rapidly evolving P. aeruginosa mutator strains and to characterize the time course of bacterial killing and resistance via mechanism-based mathematical models. Polymyxin B...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carbapenems

Share to Drug Synergism

Share to Microbial Sensitivity Tests

Share to Mutation

Share to Polymyxin B

Share to Pseudomonas aeruginosa

Source

Open in PubMed Open full text

Identifiers

PMID: 26926641
DOI: 10.1128/AAC.02377-15
PMCID: PMC4862466

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Optimization of Polymyxin B in Combination with Doripenem To Combat Mutator Pseudomonas aeruginosa.PMID 26926641Read ↗

Optimization of a Meropenem-Tobramycin Combination Dosage Regimen against Hypermutable and Nonhypermutable Pseudomonas aeruginosa via Mechanism-Based Modeling and the Hollow-Fiber Infection Model.Semantic proximity Read ↗

Mutational signature analysis predicts bacterial hypermutation and multidrug resistance.Semantic proximity Read ↗

Mutational signature analysis predicts bacterial hypermutation and multidrug resistanceSemantic proximity Read ↗

Emergence of polymyxin B resistance influences pathogenicity in Pseudomonas aeruginosa mutators.Semantic proximity Read ↗

Dynamics of mutator and antibiotic-resistant populations in a pharmacokinetic/pharmacodynamic model of Pseudomonas aeruginosa biofilm treatment.Semantic proximity Read ↗

Hypermutation is a key factor in development of multiple-antimicrobial resistance in Pseudomonas aeruginosa strains causing chronic lung infections.Semantic proximity Read ↗

Pseudomonas aeruginosa deficient in 8-oxodeoxyguanine repair system shows a high frequency of resistance to ciprofloxacin.Semantic proximity Read ↗

Antibiotic resistance in Pseudomonas aeruginosa strains with increased mutation frequency due to inactivation of the DNA oxidative repair system.Semantic proximity Read ↗

Rapid fluoroquinolone resistance detection in<i>Pseudomonas aeruginosa</i>using mismatch amplification mutation assay-based real-time PCRSemantic proximity Read ↗

The combination of meropenem and levofloxacin is synergistic with respect to both Pseudomonas aeruginosa kill rate and resistance suppression.Semantic proximity Read ↗

Development of antibiotic resistance and up-regulation of the antimutator gene pfpI in mutator Pseudomonas aeruginosa due to inactivation of two DNA oxidative repair genes (mutY, mutM).Semantic proximity Read ↗

The role of mutators in the emergence of antibiotic-resistant bacteria.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.