Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrated metabolomic and transcriptomic analyses of the synergistic effect of polymyxin–rifampicin combination against Pseudomonas aeruginosa

30 Oct 2022

Abstract excerpt

BACKGROUND: Understanding the mechanism of antimicrobial action is critical for improving antibiotic therapy. For the first time, we integrated correlative metabolomics and transcriptomics of Pseudomonas aeruginosa to elucidate the mechanism of synergistic killing of polymyxin-rifampicin combination. METHODS: Liquid chromatography-mass spectrometry and RNA-seq analyses were conducted to identify the significant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotic Resistance in Bacteria
Share to Bacterial biofilms and quorum sensing
Share to Microbial Natural Products and Biosynthesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36310165
DOI: 10.1186/s12929-022-00874-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrated metabolomic and transcriptomic analyses of the synergistic effect of polymyxin–rifampicin combination against Pseudomonas aeruginosaPMID 36310165Read ↗

Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosaSemantic proximity Read ↗

Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant Acinetobacter baumanniiSemantic proximity Read ↗

PAMDB: a comprehensive Pseudomonas aeruginosa metabolome databaseSemantic proximity Read ↗

Micafungin effect on Pseudomonas aeruginosa metabolome, virulence and biofilm: potential quorum sensing inhibitorSemantic proximity Read ↗

Synergistic effect of polymyxin B with baicalein against mcr-1 postive Escherichia coliSemantic proximity Read ↗

Combatting Pseudomonas aeruginosa with β-Lactam Antibiotics: A Revived Weapon?Semantic proximity Read ↗

Synergistic antibacterial and anti-biofilm activities of resveratrol and polymyxin B against Multidrug-resistant Pseudomonas aeruginosaSemantic proximity Read ↗

Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumanniiSemantic proximity Read ↗

Untargeted Metabolomics Reveals Species-Specific Metabolite Production and Shared Nutrient Consumption by Pseudomonas aeruginosa and Staphylococcus aureusSemantic proximity Read ↗

Transcriptomic interplay between <i>Acinetobacter baumannii</i> , human macrophage and polymyxinSemantic proximity Read ↗

Polymyxin Resistance in Acinetobacter baumannii: Genetic Mutations and Transcriptomic Changes in Response to Clinically Relevant Dosage Regimens.Semantic proximity Read ↗

Annotation of the Staphylococcus aureus Metabolome Using Liquid Chromatography Coupled to High-Resolution Mass Spectrometry and Application to the Study of Methicillin ResistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.