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Article

Semimechanistic pharmacokinetic-pharmacodynamic model with adaptation development for time-kill experiments of ciprofloxacin against Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 1 Jun 2010

Grégoire Nicolas, Raherison Sophie, Grignon Claire, Comets Emmanuelle, Marliat Manuella, Ploy Marie-Cécile, Couet William

Abstract excerpt

The objective of this study was to implement a semimechanistic pharmacokinetic-pharmacodynamic (PK-PD) model to describe the effects of ciprofloxacin against Pseudomonas aeruginosa in vitro. Time-kill curves were generated with an initial inoculum close to 5 x 10(6)CFU/ml of P. aeruginosa PAO1 and constant ciprofloxacin concentrations between 0.12 and 4.0 microg/ml (corresponding to 0.5x and 16x MIC). To support...

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Identifiers

PMID: 20368392
DOI: 10.1128/AAC.01478-08
PMCID: PMC2876392

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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