Article
VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis.
Genes and immunity - 1 Jan 2017
Guerreiro-Cacais A O, Norin U, Gyllenberg A, Berglund R, Beyeen A D, Petit-Teixeira E, Cornélis F, Saoudi A, Fournié G J, Holmdahl R, Alfredsson L, Klareskog L, Jagodic M, Olsson T, Kockum I, Padyukov L
Abstract excerpt
Rheumatoid arthritis (RA) patients can be stratified into two subgroups defined by the presence or absence of antibodies against citrullinated circular peptides (anti-CCP) with most of the genetic association found in anti-CCP positive RA. Here we addressed the role of VAV1, previously associated to multiple sclerosis (MS), in the pathogenesis of RA in experimental models and in a genetic association study....
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