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Article

Comparison of envelope 2 CD81 binding regions in PBMC-derived versus serum-derived hepatitis C virus isolates: higher conservation of CD81 region 2 in PBMC isolates.

Journal of viral hepatitis - 1 Mar 2011

Welker M-W, Welsch C, Ochs D, Hofmann W P, Herrmann E, Piiper A, Hartmann R W, Zeuzem S, Sarrazin C, Kronenberger B

Abstract excerpt

UNLABELLED: The aim of the present study was to investigate the variability of hepatitis C virus (HCV) CD81 binding regions (CD81-1/2) in peripheral blood mononuclear cells (PBMC)-derived and serum-derived HCV-RNA samples. HCV-RNA was isolated from PBMC (10⁴ cells) and serum samples from 37 patients chronically infected with HCV genotype 1a/1b (n=21/16). The hypervariable regions 1/2 (amino acid 384-410, amino...

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Identifiers

PMID: 20367804
DOI: 10.1111/j.1365-2893.2010.01296.x

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