Article
Structural features of envelope proteins on hepatitis C virus-like particles as determined by anti-envelope monoclonal antibodies and CD81 binding.
Virology - 20 Jun 2002
Triyatni Miriam, Vergalla John, Davis Anthony R, Hadlock Kenneth G, Foung Steven K H, Liang T Jake
Abstract excerpt
The envelope glycoprotein E2 of hepatitis C virus (HCV) is a major component of the viral envelope. Knowledge of its topologic features and antigenic determinants in virions is crucial in understanding the viral binding sites to cellular receptor(s) and the induction of neutralizing antibodies. The lack of a robust cell culture system for virus propagation has hampered the characterization of E2 presented on the...
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