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Article

Substitution of the CD81 Binding Site and β-Sandwich Area in E2 of HCV in Cambodia.

Viruses - 16 May 2020

Yamamoto Chikako, Nagashima Shintaro, Chuon Channarena, Ko Ko, Huy Do Son, Lim Oline, Hok Sirany, Svay Somana, Matsuo Junko, Katayama Keiko, Takahashi Kazuaki, Tanaka Junko

Abstract excerpt

The high genetic variability of hepatitis C virus (HCV) is the main obstacle to developing a vaccine. E2 has attracted attention for vaccine development because targeting this protein could potentially overcome issues related to the genetic diversity of HCV. In this study, we analyzed HCV genes in the general population of Cambodia and investigated the E2 locus as a candidate for vaccine development. HCV...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32429467
DOI: 10.3390/v12050551
PMCID: PMC7290788

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