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Article

The propeptide precursor proSAAS is involved in fetal neuropeptide processing and body weight regulation.

Journal of neurochemistry - 1 Jun 2010

Morgan Daniel J, Wei Suwen, Gomes Ivone, Czyzyk Traci, Mzhavia Nino, Pan Hui, Devi Lakshmi A, Fricker Lloyd D, Pintar John E

Abstract excerpt

Mice with a targeted mutation in proSAAS have been generated to investigate whether peptides derived from this precursor could function as an inhibitor of prohormone convertase 1/3 (PC1/3) in vivo as well as to determine any alternate roles for proSAAS in nervous and endocrine tissues. Fetal mice lacking proSAAS exhibit complete, adult-like processing of prodynorphin in the prenatal brain instead of the...

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Identifiers

PMID: 20367757
DOI: 10.1111/j.1471-4159.2010.06706.x
PMCID: PMC3510705

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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