Article
Selective sweep suggests transcriptional regulation may underlie Plasmodium vivax resilience to malaria control measures in Cambodia.
Proceedings of the National Academy of Sciences of the United States of America - 13 Dec 2016
Parobek Christian M, Lin Jessica T, Saunders David L, Barnett Eric J, Lon Chanthap, Lanteri Charlotte A, Balasubramanian Sujata, Brazeau Nicholas, DeConti Derrick K, Garba Deen L, Meshnick Steven R, Spring Michele D, Chuor Char Meng, Bailey Jeffrey A, Juliano Jonathan J
Abstract excerpt
Cambodia, in which both Plasmodium vivax and Plasmodium falciparum are endemic, has been the focus of numerous malaria-control interventions, resulting in a marked decline in overall malaria incidence. Despite this decline, the number of P vivax cases has actually increased. To understand better the factors underlying this resilience, we compared the genetic responses of the two species to recent selective...
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