Article
Association between DPP6 polymorphism and the risk of progressive multiple sclerosis in Northern and Southern Europeans.
Neuroscience letters - 21 Nov 2012
Brambilla Paola, Esposito Federica, Lindstrom Eva, Sorosina Melissa, Giacalone Giacomo, Clarelli Ferdinando, Rodegher Mariaemma, Colombo Bruno, Moiola Lucia, Ghezzi Angelo, Capra Ruggero, Collimedaglia Laura, Coniglio Gabriella, Celius Elisabeth G, Galimberti Daniela, Sørensen Per Soelberg, Martinelli Vittorio, Oturai Annette B, Harbo Hanne F, Hillert Jan, Comi Giancarlo, Martinelli-Boneschi Filippo
Abstract excerpt
BACKGROUND: In this study, we investigated the role of the dipeptidyl-peptidase-6 (DPP6) gene in the etiopathogenesis of progressive forms of multiple sclerosis (PrMS). This gene emerged as a candidate gene in a genome-wide association study (GWAS) performed in an Italian sample of PrMS and controls in which two SNPs located in the gene (rs6956703 and rs11767658) showed evidence of association (nominal...
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