Article
RASSF1A polymorphism in familial breast cancer.
Familial cancer - 1 Sept 2010
Bergqvist J, Latif A, Roberts S A, Hadfield K D, Lalloo F, Howell A, Evans D G, Newman W G
Abstract excerpt
Inactivation or loss of the tumour suppressor Ras associated domain family 1 isoform A (RASSF1A) allele has been described in breast cancer. Recently, a missense polymorphism predicting p.A331S in RASSF1A was associated with an increased risk of breast cancer and early-onset breast cancer in BRCA1 and BRCA2 mutation carriers. We genotyped p.A331S RASSF1A in 854 independent, familial, white breast cancer patients...
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